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Never wash the mouthpiece or any part of the DISKUS. KEEP IT DRY. Serevent Diskus is a prescription inhaled LABA medicine. LABA medicines such as salmeterol xinafoate help the muscles around the airways in your lungs stay relaxed to prevent symptoms, such as wheezing, cough, chest tightness, and shortness of breath. These symptoms can happen when the muscles around the airways tighten. This makes it hard to breathe. Discard Serevent Diskus 6 weeks after removal from foil pouch or when every blister used when the dose counter reads “0” whichever comes first. Tel: 01527 505414 for help. Meyer JM, Wenzel CL, Kradjan WA. Salmeterol: a novel, long-acting beta 2-agonist. Ann Pharmacother. cabergoline

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Patients who are pregnant or nursing should contact the physician about the use of SEREVENT DISKUS. Lopez-Guillen A, Marques L, Lopez-Llorente MT et al. Salmeterol-induced vertigo. Faurschou P. Use of salmeterol in moderate to severe asthmatic patients already receiving high dose inhaled steroids. This section provides information on the proper use of a number of products that contain salmeterol. It may not be specific to Serevent. Please read with care.

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Immediate hypersensitivity reactions may occur; urticaria, angioedema, rash, bronchospasm, and anaphylaxis reported. Patients who are receiving SEREVENT DISKUS twice daily should not use additional SEREVENT for prevention of EIB. Tattersfield AE, Barnes PJ. β 2-agonists and corticosteroids: new developments and controversies. Am Rev Respir Dis.

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Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. DOD clinical practice guideline for the management of chronic obstructive pulmonary disease: complete summary. Jenkins MM, Price K, Pounsford JC et al. Safety and efficacy of salmeterol in elderly patients with asthma. Am Rev Respir Dis.

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Older adults may be more sensitive to the side effects of this drug, especially QT prolongation see above. This medicine comes with patient directions or a medication guide. Read the directions carefully before using this medicine. Continued How is it treated? Serevent inhalations should not be used more often than prescribed twice per day and proper techniques of inhalation closely followed. The xinafoate moiety has no apparent pharmacologic activity. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Close the inhalation device and reset for the next dose by sliding the thumbgrip toward the patient as far as it will go. 189 253 254 255 Do not wash the inhaler. 189 253 254 255 Do not take inhaler apart. SEREVENT and DISKUS are registered trademarks of the GSK group of companies. Use the exhaust fan in the kitchen when cooking or using the dishwasher.

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Maximum improvement in FEV 1 generally occurs within 3 hours after administration of salmeterol oral inhalation powder. And while proponents of the procedure report that patient follow-ups have not yielded any significant changes in lipid profiles, Marmur points out that most, if not all, of this information is anecdotal. Seizures, nervousness, headache, tremor, nausea, dizziness, fatigue, malaise, and insomnia associated with excessive β-adrenergic stimulation. To relieve dry mouth, suck on sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute. France as early as 1952. Ullman A, Svedmyr N "Salmeterol comparison with salbutamol in adult asthmatic patients. It is possible that some side effects of Serevent Diskus may not have been reported. But seizures can happen even when you do everything you are supposed to do. If you continue to have seizures, help is available. Ask your doctor about what services are in your area. Eliminated in feces 60% and urine 25% 1 2 25 38 188 principally as metabolites. Ball DI, Brittain RT, Coleman RA et al. Salmeterol, a novel, long-acting β 2-adrenoceptor agonist: characterization of pharmacological activity in vitro and in vivo. Br J Pharmacol. Dosage adjustments not recommended solely because of age in geriatric patients. tamoxifen

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Morris HG. Mechanisms of glucocorticoid action in pulmonary disease. Chest. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Serevent Diskus should not be used more often than recommended, at higher doses than recommended, or in conjunction with other medicines containing LABA, as an overdose may result. Clinically significant cardiovascular effects and fatalities have been reported in association with excessive use of inhaled sympathomimetic drugs. The following information addresses dosage of salmeterol in special populations. 188 When salmeterol is used in fixed combination with fluticasone propionate, dosage requirements for fluticasone propionate should be considered. Ukena D, Braun H, Koper I et al. Treatment of nocturnal asthma: salmeterol vs. theophylline. Chest. Wheeldon NM, McDevitt DG, Lipworth BJ. Do β 3-adrenoceptors mediate metabolic responses to isoprenaline. Q J Med. Available data from controlled clinical trials suggest that LABA increase the risk of asthma-related hospitalization in pediatric and adolescent patients. Anthonisen NR, Connett JE, Kiley JP et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV 1. JAMA. The information contained in the Truven Health Micromedex products as delivered by Drugs. Do not use Serevent Diskus unless your healthcare provider has taught you how to use the inhaler and you understand how to use it correctly. Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist. The common are both more likely to strike in the winter and can lead to asthma flare-ups. As with all inhaled sympathomimetic medicines, cardiac arrest and even death may be associated with an overdose of Serevent Diskus. Product Information. Severent salmeterol. General information about the safe and effective use of Serevent Diskus. Spacer devices are not recommended with the Serevent or Advair Diskus inhaler.

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Additional Adverse Reactions: Other adverse reactions not previously listed, whether considered drug-related or not by the investigators, that were reported more frequently by subjects with asthma treated with Serevent Diskus compared with subjects treated with placebo include the following: contact dermatitis, eczema, localized aches and pains, nausea, oral mucosal abnormality, pain in joint, paresthesia, pyrexia of unknown origin, sinus headache, and sleep disturbance. Ruggins NR, Milner AD. The prolonged effect of salmeterol hydroxynaphthoate on exercise induced bronchoconstriction EIB in asthmatic children. Am Rev Respir Dis. Have your treatment done in a medical environment to ensure sterility and infection control. Hold the DISKUS in a level, flat position with the mouthpiece towards you. Slide the lever away from the mouthpiece as far as it will go until it clicks. Holgate S. Comparison of inhaled salmeterol and sodium cromoglycate in adult asthmatics. Allergy. Never exhale into the DISKUS. Your senses may not work right. For example, you may notice strange smells or sounds. Drazen JM, Israel E, Boushey HA et al. Comparison of regularly scheduled with as- needed use of albuterol in mild asthma. N Engl J Med. SEREVENT DISKUS is not meant to relieve acute asthma or COPD symptoms and extra doses should not be used for that purpose. Woolcock A, Lundback B, Ringdal N et al. Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids. Am J Respir Crit Care Med. The doses should be at least 12 hours apart. Learn which of your inhalers you should use every day controller drugs and which you should use if your breathing suddenly worsens quick-relief drugs. Ask your doctor ahead of time what you should do if you have new or worsening cough or shortness of breath, wheezing, increased sputum, worsening peak flow meter readings, waking up at night with trouble breathing, if you use your quick-relief inhaler more often more than 2 days a week or if your quick-relief inhaler does not seem to be working well. Learn when you can treat sudden breathing problems by yourself and when you must get medical help right away. Cromoglycate: In clinical trials, inhaled cromolyn sodium did not alter the safety profile of salmeterol when administered concurrently. Use of Serevent Diskus as a single agent for the prevention of EIB may be clinically indicated in patients who do not have persistent asthma. In patients with persistent asthma, use of Serevent Diskus for the prevention of EIB may be clinically indicated, but the treatment of asthma should include a long-term asthma control medication, such as an inhaled corticosteroid. But it's not just the procedure that has some doctors worried. For some, a lack of control over the substances used to melt the fat is of equal or greater concern. generic clavamox purchase payment

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Where the fat goes may only be the tip of the hypodermic when it comes to potential problems with this treatment. Another issue of concern: the risk of infection and some serious consequences. Puerto Rico Residents do not qualify for vaccine products. Serevent Diskus and SEREVENT Inhalation Aerosol were compared with placebo in 2 additional randomized double-blind clinical trials in adolescent and adult subjects with mild-to-moderate asthma. Scottish Intercollegiate Guidelines Network. Guidelines on the management of asthma: a national clinical guideline. London, Eng; British Thoracic Society. 2007 Jul. If medicine alone does not control your seizures, your doctor may try one or more of these other treatments. FDA safety reviewer David Graham, MD, in November 2004 voiced concern about Serevent and other nonasthma drugs during congressional drug safety hearings. In July 2005, the FDA convened an expert panel to look at the safety of Serevent, Advair, and Foradil. As if the waters weren't murky enough, recently another iron was tossed into the fat-burning fire -- a controversy surrounding the term "lipodissolve" itself. Cheung D, Timmers MC, Zwinderman AH. Long-term effect of a long-acting β 2-adrenoceptor agonist, salmeterol, on airway hyperresponsiveness in patients with mild asthma. N Engl J Med. The relative risk indicates how many more times likely an asthma-related death occurred in the salmeterol group than in the placebo group in a 28-week treatment period. Sly RM. Effect of β-adrenoreceptor stimulants on exercise-induced asthma. Pediatrics. Lourenco RV, Cotromanes E. Clinical aerosols: I. characterization of aerosols and their diagnostic uses. Arch Intern Med. Jones PW, Bosh TK. Quality of life changes in COPD patients treated wtih salmeterol. Am J REspir Crit Care Med. Fatalities also reported in association with excessive use of inhaled sympathomimetic drugs. 188 See Excessive Use and Use With Other Long-acting β 2-Adrenergic Agonists under Cautions. Ask your healthcare provider if you are not sure.

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There are two challenges for people with in the winter. One is that they spend more time inside. Key Pharmaceuticals. Proventil HFA albuterol sulfate inhalation aerosol for oral inhalation prescribing information. Kenilworth, NJ; 1996 Aug. Twenty-six percent 26% of the subjects in these trials used between 8 and 24 inhalations of short-acting beta-agonist per day on 1 or more occasions. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Winman WH. Bronchodilator treatment in asthma: manufacturers underestimate mortality from asthma. BMJ. Salmeterol is a selective LABA. In vitro studies show salmeterol to be at least 50 times more selective for beta 2-adrenoceptors than albuterol. Although beta 2-adrenoceptors are the predominant adrenergic receptors in bronchial smooth muscle and beta 1-adrenoceptors are the predominant receptors in the heart, there are also beta 2-adrenoceptors in the human heart comprising 10% to 50% of the total beta-adrenoceptors. The precise function of these receptors has not been established, but their presence raises the possibility that even selective beta 2-agonists may have cardiac effects. The following information addresses potential interactions with salmeterol. 188 When used in fixed combination with fluticasone, consider interactions associated with fluticasone. 221 257 No formal drug interaction studies have been performed to date with the fixed-combination. QT c interval, ST-segment depression reported with β-agonists; clinical importance unknown. 188 See Coexisting Conditions under Cautions. The patient must also be a US resident. The data from the SMART trial are not adequate to determine whether concurrent use of inhaled corticosteroids or other long-term asthma control therapy mitigates the risk of asthma-related death. Salmeterol is for inhalation by mouth only. GlaxoSmithKline. Serevent Diskus salmeterol xinafoate inhalation powder prescribing information. Research Triangle Park, NC; 2010 Dec. Diaz P, Gonzalez MC, Galleguillos FR et al. Leukocytes and mediators in bronchoalveolar lavage during allergen-induced late-phase asthmatic reactions. Am Rev Respir Dis. buy cheapest piracetam online pharmacy

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Do not tilt the DISKUS. Jackson says. But since you may be more likely to need it during the cold months, make sure you review your plan before winter and keep it handy. Importance of patients receiving corticosteroid therapy not to discontinue or alter dosage of corticosteroids without consulting a clinician, even if the patient feels better after initiating salmeterol. 2 5 16 20 40 42 43 45 61 62 63 72 85 97 188 Importance of informing patients that salmeterol should not be used as a substitute for oral or inhaled corticosteroids. Sears MR. Long-acting β-agonists, tachyphylaxis, and corticosteroids. Chest. But Silverman said that as a matter of policy, he could not talk about when or if they will take any enforcement action. Serevent Diskus is a teal green plastic inhaler containing a foil blister strip. Each blister on the strip contains a white powder mix of micronized salmeterol xinafoate salt 72. Handley DA, McCullough JR, Crowther SD et al. Sympathomimetic enantiomers and asthma. Chirality. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Silverman says fat-busting injections are on the FDA's radar screen and that the agency is "looking at it closely. Do not use another dose from the Diskus device if the patient does not feel or taste the drug.

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Pedersen B, Dahl R, Larsen BB et al. The effect of salmeterol on the early- and late-phase reaction to bronchial allergen and postchallenge variation in bronchial reactivity, blood eosinophils, serum eosinophil cationic protein, and serum eosinophil protein X. Allergy. Many drugs besides salmeterol may affect the heart rhythm QT prolongation including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics such as erythromycin among others. Therefore, before using salmeterol, report all medications you are currently using to your doctor or pharmacist. Do not keep outdated medicine or medicine no longer needed. Therefore, Serevent Diskus, like all products containing sympathomimetic amines, should be used with caution in patients with cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias, and hypertension. GlaxoSmith Kline. GlaxoSmithKline clinical trial register: salmeterol studies. SLGA5011: a double-blind, randomized, placebo-controlled surveillance study of asthma event outcomes in subjects receiving either usual pharmacolotherapy of asthma or usual pharmacotherapy plus salmeterol 42 mcg twice daily. The efficacy of Serevent Diskus was demonstrated over the 12-week period with no change in effectiveness over this time period Figure 1. There were no gender- or age-related differences in safety or efficacy. No development of tachyphylaxis to the bronchodilator effect was noted in these trials. When initiating salmeterol alone or in fixed combination with fluticasone, discontinue regular use of short-acting, oral or inhaled β 2-agonists; 97 188 221 257 use a short-acting, inhaled β 2-agonist, not salmeterol alone or in fixed combination with fluticasone to relieve acute symptoms such as shortness of breath. When used for the treatment of EIB, 1 inhalation of SEREVENT DISKUS should be taken 30 minutes before exercise. United Kingdom, the Salmeterol Nationwide Surveillance SNS trial, showed results similar to the SMART trial. ceclor

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Serevent is for inhalation by mouth only. You or your child have a big decrease in your peak flow when measured as directed by your doctor. Salmeterol is not a substitute for corticosteroids; corticosteroid therapy should not be stopped or reduced in dosage when salmeterol is initiated. 1 188 226 See Concomitant Anti-inflammatory Therapy under Cautions. Check with your doctor right away if you or your child have chest pain, a fast heartbeat, nervousness, shaking of the hands or feet, noisy breathing, a feeling of choking, or tightness or irritation of the throat while using this medicine. Brusasco V, Hodder R, Miravitlles M et al. Health outcomes following treatment for six months with once daily tiotropium compared with salmeterol in patients with COPD. Thorax. Inhaled salmeterol is used to prevent asthma attacks and to treat chronic obstructive pulmonary disease COPD. It is not used to relieve an asthma attack that has already started. For relief of an asthma attack that has already started, you should use another medicine. If you do not have another medicine to use for an attack or if you have any questions about this, check with your doctor. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Inform patients that Serevent Diskus is not meant to relieve acute asthma symptoms or exacerbations of COPD and extra doses should not be used for that purpose. Advise patients to treat acute symptoms with an inhaled, short-acting beta 2-agonist such as albuterol. Provide patients with such medication and instruct them in how it should be used. Hendrick DJ, Walters EH, Lowe TA. A six month comparative study between salmeterol and salbutamol in moderate asthmatics receiving prophylaxis with inhaled corticosteroids.

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Do not use salmeterol alone or in fixed combination with fluticasone in patients with asthma adequately controlled on low or medium dosage of inhaled corticosteroids. There have been over 48 million dispensed for Serevent since introduction in 1995 and over 62 million prescriptions dispensed for Advair since introduction in 2001. It generally does not affect how well you think or learn. You can't catch epilepsy from other people like a cold and they can't catch it from you. What causes epilepsy? The effects of rising inhaled doses of salmeterol and standard inhaled doses of albuterol were studied in volunteers and in subjects with asthma. Anderson SD, Rodwell LT, DuToit J et al. Duration of protection by inhaled salmeterol in exercise-induced asthma. Chest. Use a short-acting, inhaled β 2-agonist, not salmeterol alone or in fixed combination with fluticasone to relieve acute symptoms such as shortness of breath. Hampson NB, Mueller MP. Cooling of metered-dose inhalers decreases pressure output from canisters. N Engl J Med. If you have EIB and asthma, your healthcare provider should also prescribe an asthma control medicine, such as an inhaled corticosteroid. Britton J, Pavord I, Wong C et al. β 2-agonists in asthma. Lancet. Extended-Release Suspension may produce constipation. Lefkowitz RJ, Hoffman BB, Taylor P. Neurohumoral transmission: the autonomic and somatic motor nervous systems. In: Gilman AG, Rall TW, Nies AS et al, eds. buy ampicillin 40mg tablets

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Paggario PL. Salmeterol and sustained release theophylline: a comparison in asthmatic patients. Allergy. Plasma levels of salmeterol after inhaled therapeutic doses are very low. In rats, salmeterol xinafoate is excreted in the milk. Since there are no data from controlled trials on the use of Serevent Diskus by nursing mothers, caution should be exercised when Serevent Diskus is administered to a nursing woman. Importance of informing patients of adverse effects associated with β 2-adrenergic agonists, such as palpitations, rapid heart rate, tremor, nervousness, or chest pain. PIL dated March 2014. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. GSK will also provide a new patient medication guide with Advair and Serevent prescriptions.

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Suspension may exhibit an additive CNS depression. Health Administration; 1999 Aug. Take Serevent Diskus out of the foil pouch just before you use it for the first time. Safely throw away the pouch. The DISKUS will be in the closed position. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. condyline

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Serevent Diskus contains salmeterol xinafoate. LABA medicines such as salmeterol xinafoate increase the risk of death from asthma problems. MRHDID for adults and children based on comparison of the AUCs. Fuglsang G, Vikre-Jorgensen J, Agertoft L et al. Effect of salmeterol treatment on nitric oxide level in exhaled air and dose-response to terbutaline in children with mild asthma. Pediatr Pulmonol.

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Fitzpatrick MF, Mackay T, Driver H et al. Salmeterol in nocturnal asthma: a double blind, placebo controlled trial of a long acting inhaled β 2 agonist. Do not wash the DISKUS. Crane J, Burgess CD, Graham AN et al. Hypokalaemic and electrocardiographic effects of aminophylline and salbutamol in obstructive airways disease. Aesthetic Surgery Journal in 2006 reports the vast majority of treatments performed are safe and effective. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. purchase now generic albenza usa

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The other side of the spoon is marked for a 5 mL dose. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.

The problem is that the term Lipodissolve has taken on a bit of generic meaning. McFadden ER Jr. Perspectives in β 2-agonist therapy: vox clamantis in deserto vel lux in tenebris? Serevent Diskus should be administered by the orally inhaled route only. Britton MG, Earnshaw JS, Palmer JB "A twelve month comparison of salmeterol with salbutamol in asthmatic patients. LeDoux EJ, Morris JF, Temple WP et al. Standard and double dose ipratropium bromide and combined ipratropium bromide and inhaled metaproterenol in COPD. Chest.

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